Genesys Cloud enables administrators to change the knowledge base associated with an active knowledge portal through the Messenger Configurations interface. To perform this task, users must possess specific licensing (CX 1 Digital Add-on II, CX 2, CX 2 Digital, CX 3, CX 3 Digital, CX 4, or CX AI Experience) and required permissions including Architect Flow management, Routing Message and Queue administration, and Web Deployments configuration access. The process involves navigating to Menu > Digital and Telephony > Message > Messenger Configurations, selecting New Setup, choosing the desired knowledge portal from the configuration list, and then selecting the target knowledge base from the Knowledge Base list under Components. If the selected knowledge base contains categories, users must confirm the knowledge base selection again. This functionality allows organizations to dynamically manage which knowledge resources are available through their knowledge portal deployments.