Yes, the CX Cloud from Genesys and Salesforce integration supports Virtual Desktop Infrastructure (VDI) configurations.

Agents can handle interactions in the CX Cloud, Voice for Salesforce Service Cloud console through a VDI environment. For more information, see Set Up Voice Call Audio for Virtual Desktop Users. 

Genesys Cloud uses WebRTC Media Helper in a VDI environment. For more information, see Use WebRTC Media Helper in a Virtual Desktop Infrastructure (VDI) environment.